Name: U-Blot® SOD2 Rabbit mAb
SKU: WR4029
Price: 268 USD
Availability: InStock

U-Blot® SOD2 Rabbit mAb

WR4029

Western blot analysis of lysates from Hela cells, using SOD2 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

WR4029 Western blot analysis of lysates from Hela cells, using SOD2 Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4029-50

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Product details

Background:This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016],

Specifications

Size	50μL/100μL
Target	SOD2
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	25kD
MW(Observed)	22kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0085R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	SOD2
Protein Name	Superoxide dismutase [Mn] mitochondrial
Other Name	SOD2; / Superoxide dismutase [Mn], mitochondrial
Species	Human
Gene ID	6648
Uniprot	P04179,
Species.1	Mouse
Gene ID.1	20656
Uniprot.1	P09671,
Species.2	Rat
Gene ID.2	24787
Uniprot.2	P07895
Cellular Localization	Mitochondrion matrix
Tissue Expression	Brain,Colon,Heart,Liver,Lung,Mammary carcinoma,Tongue,
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Neurodegenerative disease >> Huntington disease;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Research Areas	>>FoxO signaling pathway; / >>Peroxisome; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Huntington disease; / >>Chemical carcinogenesis - reactive oxygen species; / >>Lipid and atherosclerosis
Function	Catalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 manganese ion per subunit.,Disease:Genetic variation in SOD2 is associated with susceptibility to diabetic nephropathy [MIM:612634]; also called susceptibility to microvascular complications of diabetes type 6 (MVCD6). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,Function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,online information:Superoxide dismutase entry,online information:The Singapore human mutation and polymorphism database,PTM:Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.,similarity:Belongs to the iron/manganese superoxide dismutase family.,subunit:Homotetramer.,