Sox-8/9/17/18 Polyclonal Antibody
Ucallm_WP14545-50
Price range: $268.00 through $328.00
Product details
Background:
SRY-box 8(SOX8) Homo sapiens This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Sox-8/9/17/18 |
| Reactivity | Human, Mouse, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SOX8/9/17/18. AA range:116-165 |
| Specificity | Sox-8/9/17/18 Polyclonal Antibody detects endogenous levels of Sox-8/9/17/18 protein. |
| Gene Name | SOX8/9/17/18 |
| Protein Name | Transcription factor SOX-8/9/17/18 |
| Other Name | SOX8; / Transcription factor SOX-8; / SOX9; / Transcription factor SOX-9; / SOX17; / Transcription factor SOX-17; / SOX18; / Transcription factor SOX-18 |
| Species | Human |
| Gene ID | 30812;6662;64321;54345 |
| Uniprot | P57073;P48436;Q9H6I2;P35713, |
| Species.1 | Mouse |
| Gene ID.1 | 20681;20682;20671;20672 |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Brain,Spleen, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | |
| Function | Function:May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.,similarity:Contains 1 HMG box DNA-binding domain., |
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