Product details
Background:
SPAG4 rabbit pAb
Ucallm_WP7347-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SPAG4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SPAG4 |
| Specificity | This antibody detects endogenous levels of SPAG4 at Human, Mouse,Rat |
| Gene Name | SPAG4 SUN4 |
| Protein Name | Sperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4) |
| Other Name | |
| Species | Human |
| Gene ID | 6676 |
| Uniprot | Q9NPE6, |
| Species.1 | Mouse |
| Gene ID.1 | 245865 |
| Uniprot.1 | Q9JJF2, |
| Species.2 | Rat |
| Gene ID.2 | 83623 |
| Uniprot.2 | O55034 |
| Cellular Localization | Membrane; Multi-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, flagellum axoneme . Nucleus envelope . Nucleus inner membrane . In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Colocalized with SEPT12 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa (PubMed:25775403). . |
| Tissue Expression | Predominantly epressed in testis. Expressed in ejaculated spermatozoa (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. |
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