Product details
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SPDYA rabbit pAb
Ucallm_WP8120-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SPDYA |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 34kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SPDYA |
| Specificity | This antibody detects endogenous levels of SPDYA at Human, Mouse,Rat |
| Gene Name | SPDYA SPDY1 SPY1 |
| Protein Name | Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1) |
| Other Name | |
| Species | Human |
| Gene ID | 245711 |
| Uniprot | Q5MJ70, |
| Species.1 | Mouse |
| Gene ID.1 | 70891 |
| Uniprot.1 | Q5IBH7, |
| Species.2 | Rat |
| Gene ID.2 | 192209 |
| Uniprot.2 | Q8R496 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expressed at a slightly higher level in adrenal gland, cerebellum, small intestine, lung, prostate and trachea. Expression is cell cycle-dependent, being restricted to cells in G1/S phase. |
| Signaling_pathway | |
| Research Areas | |
| Function | Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 . Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation . Mediates cell survival during the DNA damage process through activation of CDK2 . |
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