Name: SR-1A Polyclonal Antibody
SKU: WP14563
Price: 268 USD
Availability: InStock

SR-1A Polyclonal Antibody

Ucallm_WP14563-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP14563-100

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Product details

Background:

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012],

Specifications

Size	50μL/100μL
Target	SR-1A
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	46kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human 5-HT-1A. AA range:291-340
Specificity	SR-1A Polyclonal Antibody detects endogenous levels of SR-1A protein.
Gene Name	HTR1A
Protein Name	5-hydroxytryptamine receptor 1A
Other Name	HTR1A; / ADRB2RL1; / ADRBRL1; / 5-hydroxytryptamine receptor 1A; / 5-HT-1A; / 5-HT1A; / G-21; / Serotonin receptor 1A
Species	Human
Gene ID	3350
Uniprot	P08908,
Species.1	Mouse
Gene ID.1	15550
Uniprot.1	Q64264,
Species.2	Rat
Gene ID.2	24473
Uniprot.2	P19327
Cellular Localization	Cell membrane; Multi-pass membrane protein . Cell projection, dendrite .
Tissue Expression	Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
Signaling_pathway	Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas	>>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Serotonergic synapse; / >>Taste transduction
Function	Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 1 family.,