Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],
| Size | 50μL/100μL |
| Target | SR-6 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270 |
| Specificity | SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein. |
| Gene Name | HTR6 |
| Protein Name | 5-hydroxytryptamine receptor 6 |
| Other Name | HTR6; / 5-hydroxytryptamine receptor 6; / 5-HT-6; / 5-HT6; / Serotonin receptor 6 |
| Species | Human |
| Gene ID | 3362 |
| Uniprot | P50406, |
| Species.1 | Mouse |
| Gene ID.1 | 15565 |
| Uniprot.1 | Q9R1C8, |
| Species.2 | Rat |
| Gene ID.2 | 64354 |
| Uniprot.2 | P31388 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Expressed in several human brain regions, most prominently in the caudate nucleus. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway |
| Research Areas | >>Calcium signaling pathway; / >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Serotonergic synapse |
| Function | Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus., |
