SKU: WP16530 Categories: ,

SRGN rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16530-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010],

Specifications

Size50μL/100μL
TargetSRGN
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)17kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human SRGN AA range: 30-80
SpecificityThis antibody detects endogenous levels of SRGN at Human/Mouse/Rat
Gene NameSRGN PRG PRG1
Protein NameSRGN
Other Name
SpeciesHuman
Gene ID5552
UniprotP10124,
Species.1Mouse
Gene ID.119073
Uniprot.1P13609,
Species.2Rat
Gene ID.256782
Uniprot.2P04917
Cellular LocalizationCytoplasmic granule . Cytolytic granule . Secreted, extracellular space . Golgi apparatus . Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). .
Tissue Expression
Signaling_pathway
Research Areas
FunctionFunction:Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.,induction:By EBV.,PTM:O-glcosylated; contains chondroitin sulfate and heparan sulfate.,similarity:Belongs to the serglycin family.,subcellular location:Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.,subunit:Binds to activated CD44 and to GZMB.,
Please login to post questions
Back to Top
Product has been added to your cart