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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SRGP2 rabbit pAb
SKU: WP16731 Categories: ,

SRGP2 rabbit pAb

Ucallm_WP16731-50

Price range: $268.00 through $328.00

SKU: WP16731-100
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Product details

Background:

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014],

Specifications

Size50μL/100μL
TargetSRGP2
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)118kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human SRGP2 AA range: 476-526
SpecificityThis antibody detects endogenous levels of SRGP2 at Human/Mouse/Rat
Gene NameSRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A
Protein NameSRGP2
Other Name
SpeciesHuman
Gene ID23380
UniprotO75044,
Species.1Mouse
Gene ID.114270
Uniprot.1Q91Z67,
Species.2Rat
Gene ID.2
Uniprot.2D4A208
Cellular LocalizationCell membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Cell junction, synapse, postsynaptic cell membrane . Cell projection, lamellipodium . Cytoplasmic vesicle, phagosome . Nucleus . Cytoplasm, cytosol . Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). .
Tissue Expression
Signaling_pathway
Research Areas>>Axon guidance
FunctionFunction:Putative GTPase-activating protein for Rho family small GTPases.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Probably interacts with ROBO1.,tissue specificity:Expression at low levels in placenta, kidney, and ovary, and little or no expression in all other tissues tested.,
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