Price range: $268.00 through $328.00
Background:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | SSTR4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 42kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SSTR4. AA range:155-204 |
| Specificity | SSTR4 Polyclonal Antibody detects endogenous levels of SSTR4 protein. |
| Gene Name | SSTR4 |
| Protein Name | Somatostatin receptor type 4 |
| Other Name | SSTR4; / Somatostatin receptor type 4; / SS-4-R; / SS4-R; / SS4R |
| Species | Human |
| Gene ID | 6754 |
| Uniprot | P31391, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P49660, |
| Species.2 | Rat |
| Gene ID.2 | 25555 |
| Uniprot.2 | P30937 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. |
| Tissue Expression | Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals. |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction |
| Function | Function:Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals., |
