Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016],
| Size | 50μL/100μL |
| Target | SV2A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 81kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein. AA range 30-80 |
| Specificity | SV2A Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SV2A KIAA0736 PSEC0174 |
| Protein Name | Synaptic vesicle glycoprotein 2A |
| Other Name | |
| Species | Human |
| Gene ID | 9900 |
| Uniprot | Q7L0J3, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JIS5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q02563 |
| Cellular Localization | Cell junction, synapse, presynapse . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein . Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. . |
| Tissue Expression | Brain,Brain cortex,Ovary,Retina,Teratocarcinoma, |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction |
| Research Areas | >>ECM-receptor interaction |
| Function | Function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.,miscellaneous:Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.,PTM:N-glycosylated.,PTM:Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.,similarity:Belongs to the major facilitator superfamily.,subcellular location:Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.,subunit:Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2., |
