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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SYT7 Polyclonal Antibody
SKU: WP1811 Categories: ,

SYT7 Polyclonal Antibody

Ucallm_WP1811-50

Price range: $268.00 through $328.00

SKU: WP1811-100
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Product details

Background:

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],

Specifications

Size50μL/100μL
TargetSYT7
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)44kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificitySYT7 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSYT7 PCANAP7
Protein NameSynaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII)
Other Name
SpeciesHuman
Gene ID9066
UniprotO43581,
Species.1Mouse
Gene ID.1
Uniprot.1Q9R0N7
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Single-pass membrane protein . Cell junction, synapse, presynaptic cell membrane; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein . Lysosome membrane; Single-pass membrane protein . Cytoplasmic vesicle, phagosome membrane; Single-pass membrane protein . Peroxisome membrane; Single-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein . Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. .
Tissue ExpressionExpressed in a variety of adult and fetal tissues.
Signaling_pathway
Research Areas
Functioncofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domains.,Domain:The second C2 domain/C2B is responsible for SYNCRIP binding.,Function:May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.,similarity:Belongs to the synaptotagmin family.,similarity:Contains 2 C2 domains.,subunit:Interacts with SYNCRIP isoform 3 C-terminus.,tissue specificity:Expressed abundantly in brain (frontal and temporal lobes, hippocampus, hypothalamus, amygdala, substantia nigra, and pituitary), kidney, and prostate. Expressed in fetal brain, kidneys and lung.,tissue specificity:Expressed in a variety of adult and fetal tissues.,
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