Product details
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SYTL2 rabbit pAb
Ucallm_WP8916-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | SYTL2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 103kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human SYTL2 |
| Specificity | This antibody detects endogenous levels of SYTL2 at Human, Mouse |
| Gene Name | SYTL2 KIAA1597 SGA72M SLP2 SLP2A |
| Protein Name | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) |
| Other Name | |
| Species | Human |
| Gene ID | 54843 |
| Uniprot | Q9HCH5, |
| Species.1 | Mouse |
| Gene ID.1 | 83671 |
| Uniprot.1 | Q99N50 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform 1]: Cytoplasm . Cell membrane . Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. .; [Isoform 4]: Cell membrane . In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. . |
| Tissue Expression | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
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