SKU: WP14653 Categories: ,

T2R3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14653-100
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Product details

Background:

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetT2R3
ReactivityHuman, Mouse, Rat
ApplicationsIF, ELISA
MW(Calculated)36kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications;
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TAS2R3. AA range:140-189
SpecificityT2R3 Polyclonal Antibody detects endogenous levels of T2R3 protein.
Gene NameTAS2R3
Protein NameTaste receptor type 2 member 3
Other NameTAS2R3; / Taste receptor type 2 member 3; / T2R3
SpeciesHuman
Gene ID50831
UniprotQ9NYW6,
Species.1Mouse
Gene ID.1
Uniprot.1Q7TQA7
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationMembrane; Multi-pass membrane protein.
Tissue ExpressionExpressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.
Signaling_pathway
Research Areas>>Taste transduction
FunctionFunction:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the antrum and fundus (part of the stomach), duodenum and in gastric endocrine cells.,
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