Name: TAB2 Monoclonal Antibody
SKU: WM0436
Price: 268 USD
Availability: InStock

Product details

Background:
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Specifications

Target	TAB2
Reactivity	Human
Applications	WB, FC, ELISA
MW(Calculated)	76kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	Affinity purification
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	17G12
Immunogen	Purified recombinant fragment of human TAB2 expressed in E. Coli.
Sequence
Specificity	TAB2 Monoclonal Antibody detects endogenous levels of TAB2 protein.
Gene Name	TAB2 KIAA0733 MAP3K7IP2
Protein Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Other Name	TAB2; / KIAA0733; / MAP3K7IP2; / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; / Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; / TAK1-binding protein 2; / TAB-2; / TGF-beta-activated kinase 1-binding protein 2
Species	Human
Gene ID-1	23118
Uniprot	Q9NYJ8
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Cellular Localization	Membrane; Peripheral membrane protein . Endosome membrane; Peripheral membrane protein . Lysosome membrane; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
Tissue Expression	Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Signaling_pathway	Organismal Systems >> Immune system >> Toll-like receptor signaling pathway;Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Research Areas	>>MAPK signaling pathway; / >>NF-kappa B signaling pathway; / >>Osteoclast differentiation; / >>Toll-like receptor signaling pathway; / >>NOD-like receptor signaling pathway; / >>IL-17 signaling pathway; / >>TNF signaling pathway; / >>Alcoholic liver disease; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection; / >>Leishmaniasis; / >>Toxoplasmosis; / >>Hepatitis B; / >>Measles; / >>Herpes simplex virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>Coronavirus disease - COVID-19; / >>Lipid and atherosclerosis
Function	Function:Adapter linking MAP3K7/TAK1 and TRAF6 and mediator of MAP3K7 activation in the IL1 signaling pathway.,PTM:Phosphorylated.,PTM:Ubiquitinated; following IL1 stimulation or TRAF6 overexpression.,similarity:Contains 1 CUE domain.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Following IL1 stimulation, translocation occurs from the membrane to cytosol.,subunit:Interacts with MAP3K7 and TRAF6. Interacts with NCOR1 and HDAC3 to form a ternary complex.,tissue specificity:Widely expressed.,
RRID

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TAB2 Monoclonal Antibody

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TAB2 Monoclonal Antibody

Product details

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