SKU: WP15681 Categories: ,

TASK-1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15681-100
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Product details

Background:

This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008],

Specifications

Size50μL/100μL
TargetTASK-1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)53kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human TASK-1. AA range:47-96
SpecificityTASK-1 Polyclonal Antibody detects endogenous levels of TASK-1 protein.
Gene NameKCNK3
Protein NamePotassium channel subfamily K member 3
Other NameKCNK3; / TASK; / TASK1; / Potassium channel subfamily K member 3; / Acid-sensitive potassium channel protein TASK-1; / TWIK-related acid-sensitive K; / +; / channel 1; / Two pore potassium channel KT3.1; / Two pore K; / +; / channel KT3.1
SpeciesHuman
Gene ID3777
UniprotO14649,
Species.1Mouse
Gene ID.116527
Uniprot.1O35111,
Species.2Rat
Gene ID.229553
Uniprot.2O54912
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionWidespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
Signaling_pathwayOrganismal Systems >> Endocrine system >> Aldosterone synthesis and secretion
Research Areas>>Aldosterone synthesis and secretion; / >>Cortisol synthesis and secretion; / >>Cushing syndrome
FunctionFunction:pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.,miscellaneous:Inhibited by external acidification. Activated by halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.,
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