Product details
Background:
- Please choose product options by visiting TBX15/18 Polyclonal Antibody.
- Please choose product options by visiting C9orf41 rabbit pAb.
- Please choose product options by visiting RTN1 (Isoform RTN1-C) rabbit pAb.
- Please choose product options by visiting C9orf156 rabbit pAb.
TAZ (Phospho Ser89) rabbit pAb
Ucallm_WP10523-50
Price range: $288.00 through $368.00
Specifications
| Size | 50μL/100μL |
| Target | TAZ Phospho Ser89 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 44kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized phosho peptide around human TAZ (Ser89) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat TAZ (phospho-Ser89) |
| Gene Name | WWTR1 TAZ |
| Protein Name | WW domain-containing transcription regulator protein 1 |
| Other Name | WW domain-containing transcription regulator protein 1; / Transcriptional coactivator with PDZ-binding motif |
| Species | Human |
| Gene ID | 25937 |
| Uniprot | Q9GZV5, |
| Species.1 | Mouse |
| Gene ID.1 | 97064 |
| Uniprot.1 | Q9EPK5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity). When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity). Can be retained in the nucleus by MED15 (PubMed:18568018). Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499). At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity). . |
| Tissue Expression | Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway - multiple species |
| Research Areas | >>Hippo signaling pathway; / >>Hippo signaling pathway - multiple species |
| Function | Domain:Binds to transcription factors via its WW domain.,Domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.,Function:Functions as a transcriptional coactivator.,PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export.,similarity:Contains 1 WW domain.,subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ.,subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP.,tissue specificity:Highly expressed in kidney, heart, placenta and lung., |
Please login to post questions
Related products
