TBLR1 mouse mAb
Ucallm_WM0587-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016],
Specifications
| Size | 50μL/100μL |
| Target | TBLR1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, ICC |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000; ICC 1:200 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 1F8 |
| Immunogen | Purified recombinant human TBLR1 protein fragments expressed in E.coli. |
| Specificity | This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins. |
| Gene Name | TBL1XR1 |
| Protein Name | F-box-like/WD repeat-containing protein TBL1XR1 |
| Other Name | TBL1XR1; / C21; / DC42; / F box like/WD repeat containing protein TBL1XR1; / F-box-like/WD repeat-containing protein TBL1XR1; / FLJ12894; / IRA1; / Nuclear receptor corepressor/HDAC3 complex subunit; / Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; / TBL1 related protein 1; / TBL1-related protein 1; / TBL1R_HUMAN; / Transducin; / beta; / like 1 X linked receptor 1; / Transducin beta like 1X related protein 1; / Transducin beta-like 1X-related protein 1. |
| Species | Human |
| Gene ID | 79718 |
| Uniprot | Q9BZK7, |
| Species.1 | Mouse |
| Gene ID.1 | 81004 |
| Uniprot.1 | Q8BHJ5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway |
| Function | Domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,Function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.,tissue specificity:Ubiquitous., |
Please login to post questions
Related products
