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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/TGIF2 Polyclonal Antibody
SKU: WP1220 Categories: ,

TGIF2 Polyclonal Antibody

Ucallm_WP1220-50

Price range: $268.00 through $328.00

SKU: WP1220-100
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Product details

Background:

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010],

Specifications

Size50μL/100μL
TargetTGIF2
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)26kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityTGIF2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameTGIF2
Protein NameHomeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2)
Other Name
SpeciesHuman
Gene ID60436
UniprotQ9GZN2,
Species.1Mouse
Gene ID.1
Uniprot.1Q8C0Y1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus. Excluded from nucleoli.
Tissue ExpressionWidely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> TGF-beta signaling pathway
Research Areas>>TGF-beta signaling pathway
FunctionFunction:Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.,miscellaneous:TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.,PTM:The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway.,similarity:Belongs to the TALE/TGIF homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subcellular location:Excluded from nucleoli.,subunit:Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1.,tissue specificity:Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.,
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