Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015],
| Size | 50μL/100μL |
| Target | THOP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | THOP1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | THOP1 |
| Protein Name | Thimet oligopeptidase (Endopeptidase 24.15) (MP78) |
| Other Name | |
| Species | Human |
| Gene ID | 7064 |
| Uniprot | P52888, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C1A5, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P24155 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Brain,Lung,Placenta,Uterus, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Renin-angiotensin system |
| Research Areas | >>Renin-angiotensin system; / >>African trypanosomiasis |
| Function | Catalytic activity:Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Binds 1 zinc ion.,Function:Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.,similarity:Belongs to the peptidase M3 family.,subunit:Monomer., |
