Product details
Background:
TIAR rabbit pAb
Ucallm_WP8956-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TIAL1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 41kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TIAR |
| Specificity | This antibody detects endogenous levels of TIAR at Human, Mouse |
| Gene Name | TIAL1 |
| Protein Name | Nucleolysin TIAR (TIA-1-related protein) |
| Other Name | |
| Species | Human |
| Gene ID | 7073 |
| Uniprot | Q01085, |
| Species.1 | Mouse |
| Gene ID.1 | 21843 |
| Uniprot.1 | P70318 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Cytoplasm . Cytolytic granule . Cytoplasm, Stress granule . Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). . |
| Tissue Expression | Expressed in brain, heart, kidney, lung and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation . Shows a preference for uridine-rich RNAs . Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 . Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) . Possesses nucleolytic activity against cytotoxic lymphocyte target cells . May be involved in apoptosis . |
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