TMEM175 rabbit pAb
Ucallm_WP6344-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TMEM175 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 55kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMEM175 |
| Specificity | This antibody detects endogenous levels of TMEM175 at Human, Mouse,Rat |
| Gene Name | TMEM175 |
| Protein Name | Transmembrane protein 175 |
| Other Name | |
| Species | Human |
| Gene ID | 84286 |
| Uniprot | Q9BSA9, |
| Species.1 | Mouse |
| Gene ID.1 | 72392 |
| Uniprot.1 | Q9CXY1, |
| Species.2 | Rat |
| Gene ID.2 | 305623 |
| Uniprot.2 | Q6AY05 |
| Cellular Localization | Endosome membrane; Multi-pass membrane protein . Lysosome membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes . Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion . Constitutes the major lysosomal potassium channel . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage . |
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