Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human TMEM27
Specificity
This antibody detects endogenous levels of TMEM27 at Human, Mouse,Rat
Gene Name
TMEM27 UNQ679/PRO1312
Protein Name
Collectrin (Transmembrane protein 27)
Other Name
Species
Human
Gene ID
57393
Uniprot
Q9HBJ8,
Species.1
Mouse
Gene ID.1
57394
Uniprot.1
Q9ESG4,
Species.2
Rat
Gene ID.2
57395
Uniprot.2
Q9ESG3
Cellular Localization
Cell membrane; Single-pass type I membrane protein . Localizes to the brush border membranes of cells in the proximal tubules of kidney (By similarity). Colocalizes with SLC6A19 in the early proximal S1 tubule (By similarity). .
Tissue Expression
Kidney; collecting ducts. Pancreas; beta cells of islets.
Signaling_pathway
Research Areas
Function
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function . Stimulator of beta cell replication .