Price range: $268.00 through $328.00
Background:
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008],
| Size | 50μL/100μL |
| Target | TMOD2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMOD2 AA range: 138-188 |
| Specificity | This antibody detects endogenous levels of TMOD2 at Human/Mouse/Rat |
| Gene Name | TMOD2 NTMOD |
| Protein Name | TMOD2 |
| Other Name | Tropomodulin-2; / Neuronal tropomodulin; / N-Tmod |
| Species | Human |
| Gene ID | 29767 |
| Uniprot | Q9NZR1, |
| Species.1 | Mouse |
| Gene ID.1 | 50876 |
| Uniprot.1 | Q9JKK7, |
| Species.2 | Rat |
| Gene ID.2 | 58814 |
| Uniprot.2 | P70566 |
| Cellular Localization | Cytoplasm, cytoskeleton . |
| Tissue Expression | Neuronal-tissue specific. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.,similarity:Belongs to the tropomodulin family.,subunit:Binds to the N-terminus of tropomyosin and to actin.,tissue specificity:Neuronal-tissue specific., |
