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TMPRSS4 rabbit pAb
Ucallm_WP6014-50
Price range: $268.00 through $328.00
Product details
Background:
Specifications
| Size | 50μL/100μL |
| Target | TMPRSS4 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TMPRSS4 |
| Specificity | This antibody detects endogenous levels of TMPRSS4 at Human, Mouse |
| Gene Name | TMPRSS4 TMPRSS3 UNQ776/PRO1570 |
| Protein Name | Transmembrane protease serine 4 (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) |
| Other Name | |
| Species | Human |
| Gene ID | 56649 |
| Uniprot | Q9NRS4, |
| Species.1 | Mouse |
| Gene ID.1 | 214523 |
| Uniprot.1 | Q8VCA5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein .; [Transmembrane protease serine 4 catalytic chain]: Secreted . Activated by cleavage and secreted. . |
| Tissue Expression | High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436). |
| Signaling_pathway | |
| Research Areas | |
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity . Seems to be capable of activating ENaC (By similarity).; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. |
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