Name: TRα Polyclonal Antibody
SKU: WP14874
Price: 268 USD
Availability: InStock

TRα Polyclonal Antibody

Ucallm_WP14874-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP14874-100

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Product details

Background:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TRα
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Thyroid Hormone Receptor alpha. AA range:10-59
Specificity	TRα Polyclonal Antibody detects endogenous levels of TRα protein.
Gene Name	THRA
Protein Name	Thyroid hormone receptor alpha
Other Name	THRA; / EAR7; / ERBA1; / NR1A1; / THRA1; / THRA2; / Thyroid hormone receptor alpha; / Nuclear receptor subfamily 1 group A member 1; / V-erbA-related protein 7; / EAR-7; / c-erbA-1; / c-erbA-alpha
Species	Human
Gene ID	7067
Uniprot	P10827,
Species.1	Mouse
Gene ID.1	21833
Uniprot.1	P63058,
Species.2	Rat
Gene ID.2	81812
Uniprot.2	P63059
Cellular Localization	Nucleus.; [Isoform Alpha-2]: Cytoplasm . Nucleus . When overexpressed found in the cytoplasm where it colocalizes with TACC1. .
Tissue Expression	Brain,Brain cortex,Hippocampus,Kidney,Muscle,Testis,
Signaling_pathway	Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway
Research Areas	>>Neuroactive ligand-receptor interaction; / >>Thyroid hormone signaling pathway
Function	Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Nuclear hormone receptor. High affinity receptor for triiodothyronine.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13.,

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TRα Polyclonal Antibody

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TRα Polyclonal Antibody

Product details

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