Name: Trk C Monoclonal Antibody
SKU: WM0452
Price: 268 USD
Availability: InStock

Trk C Monoclonal Antibody

Ucallm_WM0452-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM0452-50

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Product details

Background:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

Specifications

Size	50μL/100μL
Target	Trk C
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	94kD
MW(Observed)
Host Species	Mouse
Isotype
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	Affinity purification
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	18E6
Immunogen	Purified recombinant extracellular fragment of human Trk C (aa32-429) fused with hIgGFc tag expressed in HEK293 cells.
Specificity	Trk C Monoclonal Antibody detects endogenous levels of Trk C protein.
Gene Name	NTRK3
Protein Name	NT-3 growth factor receptor
Other Name	NTRK3; / TRKC; / NT-3 growth factor receptor; / GP145-TrkC; / Trk-C; / Neurotrophic tyrosine kinase receptor type 3; / TrkC tyrosine kinase
Species	Human
Gene ID	4916
Uniprot	Q16288
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Expression	Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Research Areas	>>Calcium signaling pathway; / >>Neurotrophin signaling pathway; / >>Central carbon metabolism in cancer
Function	Alternative products:Additional isoforms seem to exist,Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.,