TRPM2 rabbit pAb
Ucallm_WP3991-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016],
Specifications
| Size | 50μL/100μL |
| Target | TRPM2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 165kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRPM2 AA range: 41-91 |
| Specificity | This antibody detects endogenous levels of TRPM2 at Human/Mouse |
| Gene Name | TRPM2 EREG1 KNP3 LTRPC2 TRPC7 |
| Protein Name | TRPM2 |
| Other Name | |
| Species | Human |
| Gene ID | 7226 |
| Uniprot | O94759, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91YD4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Perikaryon . Cell projection . Cytoplasmic vesicle . Lysosome . Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). .; [Isoform 1]: Cell membrane; Multi-pass membrane protein .; [Isoform 2]: Cell membrane; Multi-pass membrane protein .; [Isoform 3]: Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway |
| Research Areas | >>NOD-like receptor signaling pathway; / >>Oxytocin signaling pathway |
| Function | Catalytic activity:ADP-ribose + H(2)O = AMP + D-ribose 5-phosphate.,Function:Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.,induction:NAD(+).,similarity:Belongs to the transient receptor family. LTrpC subfamily.,similarity:Contains 1 nudix hydrolase domain.,subunit:Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.,tissue specificity:Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes., |
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