Price range: $268.00 through $328.00
Background:
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TRPV2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF/ICC1:100-500; IP 1:50-200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TRPV2 AA range: 493-543 |
| Specificity | This antibody detects endogenous levels of TRPV2 at Human/Mouse/Rat |
| Gene Name | TRPV2 VRL |
| Protein Name | TRPV2 |
| Other Name | Transient receptor potential cation channel subfamily V member 2; / TrpV2; / Osm-9-like TRP channel 2; / OTRPC2; / Vanilloid receptor-like protein 1; / VRL-1 |
| Species | Human |
| Gene ID | 51393 |
| Uniprot | Q9Y5S1, |
| Species.1 | Mouse |
| Gene ID.1 | 22368 |
| Uniprot.1 | Q9WTR1, |
| Species.2 | Rat |
| Gene ID.2 | 29465 |
| Uniprot.2 | Q9WUD2 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cytoplasm . Melanosome . Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. . |
| Tissue Expression | Brain,Lymphoblast,Skin, |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels |
| Research Areas | >>NOD-like receptor signaling pathway; / >>Inflammatory mediator regulation of TRP channels |
| Function | Function:Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.,PTM:N-glycosylated.,PTM:Phosphorylated by PKA.,similarity:Belongs to the transient receptor family. TrpV subfamily.,similarity:Contains 6 ANK repeats.,subcellular location:Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA., |
