TTF1 [ABT237] mouse mAb
Ucallm_WM1505-50
Price range: $268.00 through $328.00
Product details
Background:
Thyroid transcription factor 1 (TTF-1) is a nuclear protein with a molecular weight of 38-40 kDa. It is the basic material for thyroid differentiation and the regulation of thyroglobulin secretion. It can promote the transport of thyroid peroxidase and iodine / sodium. TTF-1 is mainly distributed in type II alveolar epithelium, respiratory epithelium and Clara cells of thyroid and lung in adult tissues, but it is not expressed in type I alveolar epithelium. It is mainly used for the diagnosis of small cell lung cancer, the differential diagnosis of primary lung adenocarcinoma from metastatic adenocarcinoma, and the differential diagnosis of lung cancer from malignant mesothelioma and paraganglioma of pleura.
Specifications
| Size | 50μL/100μL |
| Target | TTF-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | 39kD |
| MW(Observed) | 39kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM237 |
| Immunogen | Synthesized peptide derived from human TTF1 AA range: 50-150 |
| Specificity | The antibody can specifically recognize human TTF-1 protein. |
| Gene Name | NKX2-1 NKX2A TITF1 TTF1 |
| Protein Name | Homeobox protein Nkx-2.1 |
| Other Name | NKX2-1; / NKX2A; / TITF1; / TTF1; / Homeobox protein Nkx-2.1; / Homeobox protein NK-2 homolog A; / Thyroid nuclear factor 1; / Thyroid transcription factor 1; / TTF-1 |
| Species | Human |
| Gene ID | 7080 |
| Uniprot | P43699, |
| Species.1 | Mouse |
| Gene ID.1 | 21869 |
| Uniprot.1 | P50220, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P23441 |
| Cellular Localization | Nuclear |
| Tissue Expression | Thyroid/ Lung |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in NKX2-1 are the cause of benign hereditary chorea (BHC) [MIM:118700]; also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances.,Disease:Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]. This syndrome include neurological, thyroid, and respiratory problems.,Function:Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the NK-2 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Thyroid and lung., |
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