Price range: $268.00 through $328.00
Background:
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | TTF2 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 127kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TTF2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TTF2 |
| Protein Name | Transcription termination factor 2 (Lodestar homolog) (RNA polymerase II termination factor) (Transcription release factor 2) (F2) (HuF2) |
| Other Name | |
| Species | Human |
| Gene ID | 8458 |
| Uniprot | Q9UNY4, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q5NC05 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis. |
| Tissue Expression | Aorta endothelial cell,Brain,Epithelium, |
| Signaling_pathway | |
| Research Areas | >>Thyroid hormone synthesis |
| Function | Function:DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subcellular location:Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.,subunit:Interacts with CDC5L. Part of the spliceosome., |
