TUTase Polyclonal Antibody
Ucallm_WP14903-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009],
Specifications
| Size | 50μL/100μL |
| Target | TUTase |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 95kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TUT1. AA range:291-340 |
| Specificity | TUTase Polyclonal Antibody detects endogenous levels of TUTase protein. |
| Gene Name | TUT1 |
| Protein Name | Speckle targeted PIP5K1A-regulated poly(A) polymerase |
| Other Name | TUT1; / RBM21; / Speckle targeted PIP5K1A-regulated poly; / A; / polymerase; / Star-PAP; / RNA-binding motif protein 21; / RNA-binding protein 21; / U6 snRNA-specific terminal uridylyltransferase 1; / U6-TUTase |
| Species | Human |
| Gene ID | 64852 |
| Uniprot | Q9H6E5, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8R3F9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleolus . Nucleus speckle . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:UTP + RNA(n) = diphosphate + RNA(n+1).,Function:Highly specific terminal uridylyltransferase that exclusively accepts U6 snRNA as substrate. U6 snRNA is unique in that nucleotides are both added to and removed from its 3'-end. U6-TUTase is responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain., |
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