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TWIST2 rabbit pAb
Ucallm_WP6238-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TWIST2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 18kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TWIST2 |
| Specificity | This antibody detects endogenous levels of TWIST2 at Human, Mouse,Rat |
| Gene Name | TWIST2 BHLHA39 DERMO1 |
| Protein Name | Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1) |
| Other Name | |
| Species | Human |
| Gene ID | 117581 |
| Uniprot | Q8WVJ9, |
| Species.1 | Mouse |
| Gene ID.1 | 13345 |
| Uniprot.1 | Q9D030, |
| Species.2 | Rat |
| Gene ID.2 | 59327 |
| Uniprot.2 | P97831 |
| Cellular Localization | Nucleus . Cytoplasm . Mainly nuclear during embryonic development. Cytoplasmic in adult tissues. |
| Tissue Expression | In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. |
| Signaling_pathway | |
| Research Areas | |
| Function | Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. |
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