Price range: $268.00 through $328.00
Background:
thioredoxin domain containing 5(TXNDC5) Homo sapiens This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010],
| Size | 50μL/100μL |
| Target | TXND5 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | TXND5 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | TXNDC5 TLP46 UNQ364/PRO700 |
| Protein Name | Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) |
| Other Name | |
| Species | Human |
| Gene ID | 81567 |
| Uniprot | Q8NBS9, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91W90 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum lumen . |
| Tissue Expression | Eye,Liver,Lymph,Lymph node,Ovary,PCR rescued clones,Retina,Spleen,Stomach, |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum |
| Research Areas | >>Protein processing in endoplasmic reticulum |
| Function | Function:Involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules.,Function:Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.,similarity:Belongs to the Muted family.,similarity:Belongs to the protein disulfide isomerase family.,similarity:Contains 2 thioredoxin domains.,similarity:Contains 3 thioredoxin domains.,subunit:Interacts with pallidin. Interacts with dystrobrevin binding protein 1 and CNO/cappuccino (By similarity). Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)., |
