Name: U-Blot® ACSL1 Rabbit mAb
SKU: WR5240
Price: 268 USD
Availability: InStock

U-Blot® ACSL1 Rabbit mAb

Ucallm_WR5240-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5240-100

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Product details

Background:The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],

Specifications

Size	50μL/100μL
Target	ACSL1
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	78kD
MW(Observed)	78kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1477R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	ACSL1 FACL1 FACL2 LACS LACS1 LACS2
Protein Name	Long-chain-fatty-acid--CoA ligase 1 (Acyl-CoA synthetase 1) (ACS1) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2)
Other Name
Species	Human
Gene ID	2180
Uniprot	P33121,
Species.1	Mouse
Gene ID.1
Uniprot.1	P41216,
Species.2	Rat
Gene ID.2
Uniprot.2	P18163
Cellular Localization	Mitochondrion outer membrane; Single-pass type III membrane protein . Peroxisome membrane; Single-pass type III membrane protein . Microsome membrane; Single-pass type III membrane protein . Endoplasmic reticulum membrane; Single-pass type III membrane protein .
Tissue Expression	Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas	>>Fatty acid biosynthesis; / >>Fatty acid degradation; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>Peroxisome; / >>Ferroptosis; / >>Thermogenesis; / >>Adipocytokine signaling pathway
Function	Catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,developmental stage:Expressed during the early stages of erythroid development while expression is very low in reticulocytes and young erythrocytes.,Function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,tissue specificity:Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.,

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U-Blot® ACSL1 Rabbit mAb

Product details

Specifications

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U-Blot® ACSL1 Rabbit mAb

Product details

Specifications

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