U-Blot® Cathepsin S Rabbit mAb
Ucallm_WR5423-50
Price range: $268.00 through $328.00
Product details
Background:The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010],
Specifications
| Size | 50μL/100μL |
| Target | Cathepsin S |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 38kD |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1672R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | CTSS |
| Protein Name | Cathepsin S (EC 3.4.22.27) |
| Other Name | |
| Species | Human |
| Gene ID | 1520 |
| Uniprot | P25774, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O70370, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q02765 |
| Cellular Localization | Lysosome . Secreted . Cytoplasmic vesicle, phagosome . |
| Tissue Expression | Alveolar macrophage,Pancreas,Testis, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Cellular Processes >> Cell growth and death >> Apoptosis;Organismal Systems >> Immune system >> Antigen processing and presentation |
| Research Areas | >>Lysosome; / >>Phagosome; / >>Apoptosis; / >>Antigen processing and presentation; / >>Tuberculosis |
| Function | Catalytic activity:Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.,Function:Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.,similarity:Belongs to the peptidase C1 family.,subunit:Monomer., |
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