U-Blot® CD1c Mouse mAb
Ucallm_WM1835-50
Price range: $268.00 through $328.00
Product details
Background：
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | CD1c |
| Reactivity | Human |
| Applications | FC,IF |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | Mouse IgG1/Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IF 1:200-1:1000;FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Purification | Protein A |
| Storage | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMF0039 |
| Immunogen | |
| Specificity | Endogenous |
| Gene Name | CD1C |
| Protein Name | T-cell surface glycoprotein CD1c |
| Other Name | CD1C;T-cell surface glycoprotein CD1c;CD1c |
| Species | Human |
| Gene ID | 911 |
| Uniprot | P29017 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein. Lysosome . Subject to intracellular trafficking between the cell membrane and endosomes. . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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