Price range: $268.00 through $328.00
Background:The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | Galectin-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 15kD |
| MW(Observed) | 15kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:500-1:2000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1427R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | LGALS1 |
| Protein Name | Galectin-1 |
| Other Name | LGALS1; / Galectin-1; / Gal-1; / 14 kDa laminin-binding protein; / HLBP14; / 14 kDa lectin; / Beta-galactoside-binding lectin L-14-I; / Galaptin; / HBL; / HPL; / Lactose-binding lectin 1; / Lectin galactoside-binding soluble 1; / Putative MAPK-activating protein P |
| Species | Human |
| Gene ID | 3956 |
| Uniprot | P09382, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P16045, |
| Species.2 | Rat |
| Gene ID.2 | 56646 |
| Uniprot.2 | P11762 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix . Cytoplasm . Secreted . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. . |
| Tissue Expression | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.,online information:Galectin-1,similarity:Contains 1 galectin domain.,subunit:Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45.,tissue specificity:Cardiac, smooth, and skeletal muscle, neurons, thymus, kidney, placenta and hematopoietic cells., |
