U-Blot® GATA3 Rabbit pAb
Ucallm_WP25052-50
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
Specifications
| Size | 50μL/100μL |
| Target | GATA 3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | 48kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | |
| Specificity | Endogenous |
| Gene Name | GATA3 |
| Protein Name | Trans-acting T-cell-specific transcription factor GATA-3 |
| Other Name | GATA3; / Trans-acting T-cell-specific transcription factor GATA-3; / GATA-binding factor 3 |
| Species | Human |
| Gene ID | 2625 |
| Uniprot | P23771, |
| Species.1 | Mouse |
| Gene ID.1 | 14462 |
| Uniprot.1 | P23772 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | T-cells and endothelial cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Immune disease >> Inflammatory bowel disease |
| Research Areas | >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>Parathyroid hormone synthesis, secretion and action; / >>Inflammatory bowel disease |
| Function | Disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,Function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells., |
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