Price range: $268.00 through $328.00
Background:Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
| Size | 50μL/100μL |
| Target | GCS-α-1 |
| Reactivity | Human |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 77kD |
| MW(Observed) | 70kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1617R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GUCY1A3 |
| Protein Name | Guanylate cyclase soluble subunit alpha-3 |
| Other Name | GUCY1A3; / GUC1A3; / GUCSA3; / GUCY1A1; / Guanylate cyclase soluble subunit alpha-3; / GCS-alpha-3; / GCS-alpha-1; / Soluble guanylate cyclase large subunit |
| Species | Human |
| Gene ID | 2982 |
| Uniprot | Q02108, |
| Species.1 | Mouse |
| Gene ID.1 | 60596 |
| Uniprot.1 | Q9ERL9, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P19686 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Detected in brain cortex and lung (at protein level). |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>Purine metabolism; / >>Metabolic pathways; / >>cGMP-PKG signaling pathway; / >>Vascular smooth muscle contraction; / >>Gap junction; / >>Platelet activation; / >>Circadian entrainment; / >>Long-term depression; / >>Oxytocin signaling pathway; / >>Renin secretion; / >>Salivary secretion |
| Function | Catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain., |
