U-Blot® GDF-15 Rabbit mAb
Ucallm_WR5336-50
Price range: $268.00 through $328.00
Product details
Background:growth differentiation factor 15(GDF15) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016],
Specifications
| Size | 50μL/100μL |
| Target | GDF-15 |
| Reactivity | Human |
| Applications | WB, IHC, IF, IP, ELISA |
| MW(Calculated) | 34kD |
| MW(Observed) | 35kD(pro GDF15),13kD(mature GDF15) |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:500; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1570R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | GDF15 |
| Protein Name | Growth/differentiation factor 15 |
| Other Name | GDF15; / MIC1; / PDF; / PLAB; / PTGFB; / Growth/differentiation factor 15; / GDF-15; / Macrophage inhibitory cytokine 1; / MIC-1; / NSAID-activated gene 1 protein; / NAG-1; / NSAID-regulated gene 1 protein; / NRG-1; / Placental TGF-beta; / Placental bone morphogenetic |
| Species | Human |
| Gene ID | 9518 |
| Uniprot | Q99988, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z0J7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney (PubMed:9348093). Detected in plasma (at protein level) (PubMed:28572090, PubMed:29046435). |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney., |
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