Name: U-Blot® IL-17Rα Rabbit mAb
SKU: WR5335
Price: 268 USD
Availability: InStock

U-Blot® IL-17Rα Rabbit mAb

Ucallm_WR5335-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR5335-50

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Product details

Background:Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],

Specifications

Target	IL-17Rα
Reactivity	Human
Applications	WB, IF, ELISA
MW(Calculated)	96kD
MW(Observed)	120-170kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000;
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT1569R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	IL17RA
Protein Name	Interleukin-17 receptor A
Other Name	IL17RA; / IL17R; / Interleukin-17 receptor A; / IL-17 receptor A; / IL-17RA; / CDw217; / CD antigen CD217
Species	Human
Gene ID-1	23765
Uniprot	Q96F46,
Species.1	Mouse
Gene ID-2	16172
Uniprot.1	Q60943
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],
Cellular Localization	[Isoform 1]: Cell membrane; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Tissue Expression	Widely expressed.
Signaling_pathway	Organismal Systems >> Immune system >> IL-17 signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Research Areas	>>Cytokine-cytokine receptor interaction; / >>IL-17 signaling pathway; / >>Alcoholic liver disease
Function	Function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,
RRID