Specifications
| Size | 50μL/100μL |
| Target | MAO-A |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 60kD |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1774R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | MAOA |
| Protein Name | Amine oxidase [flavin-containing] A |
| Other Name | MAOA; / Amine oxidase [flavin-containing] A; / Monoamine oxidase type A; / MAO-A |
| Species | Human |
| Gene ID | 4128 |
| Uniprot | P21397, |
| Species.1 | Mouse |
| Gene ID.1 | 17161 |
| Uniprot.1 | Q64133, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P21396 |
| Cellular Localization | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side . |
| Tissue Expression | Heart, liver, duodenum, blood vessels and kidney. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | >>Glycine, serine and threonine metabolism; / >>Arginine and proline metabolism; / >>Histidine metabolism; / >>Tyrosine metabolism; / >>Phenylalanine metabolism; / >>Tryptophan metabolism; / >>Drug metabolism - cytochrome P450; / >>Metabolic pathways; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism |
| Function | Catalytic activity:RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).,cofactor:FAD.,Disease:Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.,Function:Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.,mass spectrometry: PubMed:11812236,online information:Monoamine oxidase entry,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.,tissue specificity:Heart, liver, duodenum, blood vessels and kidney., |
