U-Blot® MCP1 Rabbit mAb
Ucallm_WR6087-50
Price range: $268.00 through $328.00
Product details
Background:This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates , like psoriasis , rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐ CoV‐ 2) infection. [provided by RefSeq , Aug 2020]
Specifications
| Size | 50μL/100μL |
| Target | MCP1 |
| Reactivity | Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 11kD |
| MW(Observed) | 20kD |
| Host Species | Rabbit |
| Isotype | IgG, Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year (Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM2123R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | MCP1, SCYA2,CCL2 |
| Protein Name | MCP1; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; Monocyte secretory protein JE |
| Other Name | |
| Species | Human |
| Gene ID | 6347 |
| Uniprot | P13500 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted |
| Tissue Expression | Expressed in the seminal plasma , endometrial fluid and follicular fluid (at protein level) ,monocytes. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> IL-17 signaling pathway;Organismal Systems >> Immune system >> Chemokine signaling pathway;Human Diseases >> Immune disease >> Rheumatoid arthritis;Environmental Information Processing >> Signal transduction >> TNF signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor |
| Research Areas | |
| Function | Acts as a ligand for C-C chemokine receptor CCR2 . ,Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions . ,Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. ,May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. , |
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