SKU: WR5412 Categories: ,

U-Blot® P2RY6 Rabbit mAb

Price range: $268.00 through $328.00

SKU: WR5412-50
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Product details

Background:The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013],

Specifications

TargetP2RY6
ReactivityHuman
ApplicationsWB, IHC, IF, IP, ELISA
MW(Calculated)36kD
MW(Observed)43kD
Host SpeciesRabbit
IsotypeIgG,Kappa
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioIHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberPT1661R
ImmunogenThe specific immunogen used to produce this antibody is proprietary information.
Sequence
SpecificityEndogenous
Gene NameP2RY6 PP2891
Protein NameP2Y purinoceptor 6 (P2Y6)
Other Name
SpeciesHuman
Gene ID-15031
UniprotQ15077,
Species.1Mouse
Gene ID-2
Uniprot.1Q9ERK9,
Species.2Rat
Gene ID-3
Uniprot.2Q63371
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013],
Cellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue ExpressionBrain,Placenta,
Signaling_pathway
Research Areas>>Neuroactive ligand-receptor interaction
FunctionFunction:Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,
RRID
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