U-Blot® Placental Alkaline Phosphatase(PLAP) Rabbit mAb (Ready to Use)
Ucallm_WR8140
$168.00
Product details
Background：
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],
Specifications
| Size | 6mL |
| Target | PLAP |
| Reactivity | Human |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | Recombinant Expression and Affinity purified |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM73R |
| Immunogen | Synthesized peptide derived from human Placental Alkaline Phosphatase(PLAP) AA range:400-500 |
| Specificity | This antibody detects endogenous levels of Placental Alkaline Phosphatase(PLAP)(PT2105) |
| Gene Name | ALPP; PLAP |
| Protein Name | Placental Alkaline Phosphatase(PLAP) |
| Other Name | Alkaline phosphatase, placental type; / Alkaline phosphatase Regan isozyme; / Placental alkaline phosphatase 1; / PLAP |
| Species | Human |
| Gene ID | 250 |
| Uniprot | P05187 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer., |
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