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U-Blot® POU3F2 Rabbit mAb
Ucallm_WR5355-50
Price range: $268.00 through $328.00
Product details
Background:This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012],
Specifications
| Size | 50μL/100μL |
| Target | POU3F2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, IP, ELISA |
| MW(Calculated) | 47kD |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1595R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | POU3F2 BRN2 OCT7 OTF7 |
| Protein Name | POU domain, class 3, transcription factor 2 (Brain-specific homeobox/POU domain protein 2) (Brain-2) (Brn-2) (Nervous system-specific octamer-binding transcription factor N-Oct-3) (Octamer-binding protein 7) (Oct-7) (Octamer-binding transcription factor 7) (OTF-7) |
| Other Name | |
| Species | Human |
| Gene ID | 5454 |
| Uniprot | P20265, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P31360, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P56222 |
| Cellular Localization | Nucleus. |
| Tissue Expression | Expressed specifically in the neuroectodermal cell lineage. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters.,similarity:Belongs to the POU transcription factor family. Class-3 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with PQBP1.,tissue specificity:Expressed specifically in the neuroectodermal cell lineage., |
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