Name: U-Blot® Research Grade Cibotercept
SKU: WA2598
Price: 9999 USD
Availability: InStock

Product details

Background：Cibotercept is an anti-MSTN/INHBA/GDF11 monoclonal antibody.
• LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854
• Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure., PMID:25051287
• ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass., PMID:29089584
• Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404
• Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946
• iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216
• BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878
• Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583
• Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade., PMID:30860875
• Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum., PMID:28929587

Specifications

Target	ACTR-IIB
Reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Mammalian Cells
Isotype	Human ACTR-IIB extracellular domain (ECD) fragment fused via the peptide linker to a human IgG1 Fc fragment
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% purity as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
Clonality
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Species
Gene ID-1	Q13705
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Cibotercept is an anti-MSTN/INHBA/GDF11 monoclonal antibody.<br>• LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854<br />• Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure., PMID:25051287<br />• ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass., PMID:29089584<br />• Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404<br />• Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946<br />• iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216<br />• BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878<br />• Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583<br />• Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade., PMID:30860875<br />• Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum., PMID:28929587<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function