Name: U-Blot® Research Grade Enokizumab
SKU: WA2796
Price: 9999 USD
Availability: InStock

U-Blot® Research Grade Enokizumab

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$9,999.00

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SKU: WA2796-50

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Product details

Background：Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.
• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612
• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066
• The Role of Interleukin-9 in Cancer., PMID:31016637
• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012
• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637
• Interleukin-9 and mast cells., PMID:23034251
• IL-9 sensitizes human T_H2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283
• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589
• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882
• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707

Specifications

Target
Reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host Species	Humanized
Isotype	IgG1-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition	0.01M PBS, pH 7.4.
Purification Process	Protein A/G purified from cell culture supernatant.
Purity	>95% as determined by SDS-PAGE.
Storage Condition	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Concentration
Clonality	Monoclonal
Clone Number
Immunogen	Mammalian Cells
Gene Name
Protein Name
Alias	T-cell growth factor P40, Cytokine P40, IL9, Interleukin-9, IL-9
Species
Gene ID-1	P15248
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Description	Background：Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.<br>• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612<br />• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066<br />• The Role of Interleukin-9 in Cancer., PMID:31016637<br />• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012<br />• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637<br />• Interleukin-9 and mast cells., PMID:23034251<br />• IL-9 sensitizes human T<sub>H</sub>2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283<br />• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589<br />• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882<br />• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function