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Home/Reagents/Antibody/Biosimilar & Bispecific Antibodies/U-Blot® Research Grade Leronlimab
SKU: WA3065 Categories: ,

U-Blot® Research Grade Leronlimab

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$9,999.00

SKU: WA3065-50
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Product details

Background：Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.
• Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19., PMID:34530915
• CCR5 blockage by maraviroc induces cytotoxic and apoptotic effects in colorectal cancer cells., PMID:25840792
• Retinopathy severity correlates with RANTES concentrations and CCR 5-positive microvesicles in diabetes., PMID:31891363
• Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression., PMID:27625334
• Acute response of peripheral CCr5 chemoreceptor and NK cells in individuals submitted to a single session of low-intensity strength exercise with blood flow restriction., PMID:25643617
• Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:27781132

Specifications

TargetCD195
ReactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
MW(Calculated)
MW(Observed)
Host SpeciesHumanized
IsotypeIgG4-kappa
Conjugate/Modification
Modification
Recommended Dilution Ratio
Composition0.01M PBS, pH 7.4.
Purification ProcessProtein A/G purified from cell culture supernatant.
Purity>95% purity as determined by SDS-PAGE.
Storage ConditionUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenMammalian Cells
Gene Name
Protein Name
AliasC-C CKR-5, CC-CKR-5, CMKBR5, HIV-1 fusion coreceptor, CHEMR13, CCR5, C-C chemokine receptor type 5, CD195, CCR-5
Species
Gene ID-1P51681
Uniprot
Species.1
Gene ID
Uniprot.1
Species.2
Gene ID.1
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
DescriptionBackground：Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.<br>• Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19., PMID:34530915<br />• CCR5 blockage by maraviroc induces cytotoxic and apoptotic effects in colorectal cancer cells., PMID:25840792<br />• Retinopathy severity correlates with RANTES concentrations and CCR 5-positive microvesicles in diabetes., PMID:31891363<br />• Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression., PMID:27625334<br />• Acute response of peripheral CCr5 chemoreceptor and NK cells in individuals submitted to a single session of low-intensity strength exercise with blood flow restriction., PMID:25643617<br />• Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:27781132<br />
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
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