U-Blot® Research Grade Ranevetmab
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$9,999.00
Product details
Background：Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.
• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244
• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273
• Effect of the Camelid’s Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816
• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191
• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645
• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420
• β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615
• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046
• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111
Specifications
| Target | NGF/Beta-NGF |
| Reactivity | Dog |
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Caninized |
| Isotype | IgG1, kappa |
| Conjugate/Modification | |
| Modification | |
| Recommended Dilution Ratio | |
| Composition | 0.01M PBS, pH 7.4. |
| Purification Process | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Storage Condition | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Mammalian Cells |
| Gene Name | |
| Protein Name | |
| Alias | NGF/Beta-NGF |
| Species | |
| Gene ID-1 | F1PDQ3 |
| Uniprot | |
| Species.1 | |
| Gene ID | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.1 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Description | Background：Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.<br>• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244<br />• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273<br />• Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816<br />• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191<br />• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908<br />• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645<br />• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420<br />• β-NGF Stimulates Steroidogenic Enzyme and <i>VEGFA</i> Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615<br />• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046<br />• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111<br /> |
| Cellular Localization | |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function |
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